Dihexa — a hexapeptide analog of angiotensin IV — is the research peptide at the centre of HGF/c-Met and synaptogenesis research. Supplied as a lyophilized 4 mg research kit, third-party HPLC-tested, shipped domestically from British Columbia.
HPLC-tested research kit · flat $30 CAD Xpresspost · CoA on every batch
Section 01 — Definition
Dihexa — a hexapeptide analog of angiotensin IV — is a small, metabolically stable research peptide developed to probe the hepatocyte growth factor (HGF) / c-Met receptor system. It was engineered from the Ang IV sequence to resist breakdown and cross into the central nervous system in research models, which is why it draws interest as a cognitive research compound.
In the literature Dihexa is described as one of the most potent known synaptogenic compounds — agents that promote the formation of new synaptic connections — with activity reported in the picomolar-to-femtomolar range in some assays. When researchers search for a cognitive or nootropic peptide to study synapse formation, Dihexa is a frequent reference compound.
Helix North supplies Dihexa strictly as a lyophilized research material for in-vitro and laboratory use. Everything on this page is written for research handling and sourcing — it is not dosing guidance and not for human use.
An angiotensin IV–derived peptide engineered for stability — Dihexa is a reference compound in synaptogenesis and HGF/c-Met research.
Section 02 — Research
What makes Dihexa distinctive is its mechanism. Rather than acting on a single classical receptor, research reports that Dihexa potentiates the hepatocyte growth factor (HGF) and its receptor c-Met — a signaling axis tied to cell growth, survival and, in the nervous system, the formation of new synapses.
| Research area | Model focus |
|---|---|
| Synaptogenesis | Dendritic-spine & synapse formation |
| HGF / c-Met | Receptor-system activation |
| Learning & memory | Cognitive animal models |
| Neurodegeneration | Neuroprotection models |
A recurring thread is synaptogenesis — Dihexa is studied for its ability to drive the formation of new synaptic connections, which is why cognitive and neurodegeneration models feature heavily in the literature. This is preclinical, mechanism-level, in-vitro and animal research; none of it constitutes evidence of a human therapeutic effect.
Researchers working the cognitive line often study Dihexa alongside other nootropic research peptides — see our Selank & Semax nootropic research overview, and browse the full nootropic research shelf.
Section 03 — Product
Dihexa is stocked as a lyophilized 4 mg research kit. Because it is studied at very low concentrations, a single 4 mg kit goes a long way in a research setting. It ships freeze-dried with a Certificate of Analysis for its specific lot.
Every lot is sent to an independent third-party laboratory for HPLC purity analysis. The Certificate of Analysis — including the lot number and chromatogram — is published on the product page so you can review the result before ordering, and a lot that falls below specification is not released.
Researchers working across the cognitive-peptide line often pair Dihexa with other nootropic research peptides such as Semax and Selank. See the kit below, or read how each lot is tested on our lab testing and CoA page.
Section 04 — Handling
Dihexa ships freeze-dried and is reconstituted with bacteriostatic water before use. The diluent volume is the only real decision, because it sets the concentration of the finished research stock — concentration is simply mass divided by volume.
Wipe the stopper with an alcohol prep pad, draw the chosen volume of bacteriostatic water into an insulin syringe, and add it slowly down the inside wall of the vial. Swirl gently until dissolved — never shake — then refrigerate at 2 to 8°C. Because Dihexa is studied at low concentrations, researchers often reconstitute to a dilute stock so a workable volume can be measured accurately.
Our peptide storage and handling guide covers stability in detail, and the Dihexa research guide walks through the compound end to end. These are reconstitution mechanics for laboratory handling only — not dosing recommendations, and not for human use.
Section 05 — Sourcing
Sourcing Dihexa domestically removes the two problems that come with an offshore order: the customs wait and the currency markup. A Canadian-domestic shipment never crosses a border, so there is no customs hold and no risk of a package being detained or returned mid-protocol.
Helix North makes its peptides in Canada and ships Dihexa from British Columbia by Canada Post Xpresspost — 1 to 2 business days on the West Coast, 2 to 4 for central Canada, a flat $30 to any postal code, tracked and in plain packaging. Pricing is in Canadian dollars, so the number on the product page is the number on the receipt.
Dihexa is legal to purchase and possess for research in Canada and is not a controlled substance. It is supplied strictly as a research material. New here? The Canadian research peptides overview covers testing and shipping across the whole catalog.
Section 06 — Common questions
Get the lyophilized 4 mg Dihexa kit with a third-party HPLC CoA, or explore the wider nootropic research line. Questions about lots or bulk quantities — get in touch.