KPV — the lysine-proline-valine C-terminal fragment of α-MSH — is the tripeptide studied for anti-inflammatory signaling that appears independent of the melanocortin receptors. Supplied as a lyophilized 10 mg research vial, third-party HPLC tested, shipped domestically from British Columbia.
Anti-inflammatory research vials · flat $30 CAD Xpresspost · CoA on every batch
Section 01 — Definition
KPV is a tripeptide — lysine, proline and valine (Lys-Pro-Val) — the C-terminal fragment of α-MSH (alpha-melanocyte-stimulating hormone). It carries the anti-inflammatory activity of the parent hormone without α-MSH’s pigmentary, melanocortin-driven activity.
Because it is only three residues, KPV is small and stable, and in preclinical research it appears to enter cells and act on intracellular inflammatory pathways rather than through cell-surface melanocortin receptors. When people search for the KPV peptide, this α-MSH fragment is the compound they mean.
Helix North supplies KPV strictly as a lyophilized research material for in-vitro and laboratory use. Everything on this page is written for research handling and sourcing — it is not dosing guidance and not for human use.
A three-residue fragment of α-MSH — KPV carries the parent hormone’s anti-inflammatory signature without its pigmentary activity.
Section 02 — Research
What makes KPV notable is a broad anti-inflammatory profile across preclinical models. Published research reports downregulation of NF-κB signaling and reduced pro-inflammatory cytokine production — such as TNF-α and IL-6 — in several different model systems.
| Research area | Model focus |
|---|---|
| Gut inflammation | Colitis / IBD models |
| Skin & wound | Healing & re-epithelialization |
| Immune signaling | NF-κB & cytokine modulation |
| Mast cells | Allergic / inflammatory response |
A recurring theme is that KPV appears to act intracellularly and independently of the melanocortin receptors, which is part of why it is studied as a “clean” anti-inflammatory fragment. This is preclinical, mechanism-level research; none of it is evidence of a human therapeutic effect.
KPV is frequently paired with BPC-157 in gut- and recovery-focused research, and it is one of the four peptides in the KLOW repair blend (BPC-157 + TB-500 + KPV + GHK-Cu). See our BPC-157 in Canada guide and the KLOW blend for the combination context.
Section 03 — Product
KPV is stocked as a lyophilized 10 mg research vial, and as an oral BPC+KPV capsule (500 mcg each) for researchers pairing it with BPC-157. Each vial ships freeze-dried with a Certificate of Analysis for its specific lot.
Every lot is sent to an independent third-party laboratory for HPLC purity analysis, and the CoA — including the lot number and chromatogram — is published on the product page so you can review it before ordering. A lot that falls below specification is not released.
KPV is also the anti-inflammatory component of the KLOW blend. Choose a format below, or read how each lot is tested on our lab testing and CoA page.
Section 04 — Handling
KPV ships freeze-dried and is reconstituted with bacteriostatic water before use. The diluent volume is the only real decision, because it sets the concentration of the finished research stock — concentration is simply mass divided by volume.
Wipe both stoppers with an alcohol prep pad, draw the chosen volume of bacteriostatic water into an insulin syringe, and add it slowly down the inside wall of the vial. Swirl gently until dissolved — never shake — then refrigerate at 2 to 8°C. A 10 mg vial reconstituted with 2 mL gives a 5 mg/mL stock.
The oral BPC+KPV capsule needs no reconstitution. Our peptide storage and handling guide covers stability in detail. These are reconstitution mechanics for laboratory handling only — not dosing recommendations.
Section 05 — Sourcing
Sourcing KPV domestically removes the two problems that come with an offshore order: the customs wait and the currency markup. A Canadian-domestic shipment never crosses a border, so there is no customs hold and no risk of a package being detained or returned mid-protocol.
Helix North makes its peptides in Canada and ships KPV from British Columbia by Canada Post Xpresspost — 1 to 2 business days on the West Coast, 2 to 4 for central Canada, a flat $30 to any postal code, tracked and in plain packaging. Pricing is in Canadian dollars, so the number on the product page is the number on the receipt.
KPV is legal to purchase and possess for research in Canada and is not a controlled substance. It is supplied strictly as a research material. New here? The Canadian research peptides overview covers testing and shipping across the whole catalog.
Section 06 — Common questions
Choose a lab-tested 10 mg vial, the oral BPC+KPV capsule, or KPV in the KLOW repair blend — each with a third-party CoA. Questions about lots or bulk quantities — get in touch.