TB-500 is a synthetic peptide based on Thymosin Beta-4, studied for tissue repair, cell migration, and angiogenesis in preclinical research. Supplied as a lyophilized research peptide in 10 mg vials, 99%+ HPLC purity, third-party tested, shipped domestically from British Columbia.
Lab-tested research doses · flat $30 CAD Xpresspost · CoA on every batch
Section 01 — Definition
TB-500 is a synthetic peptide built around the active region of Thymosin Beta-4 (TΒ4), a naturally occurring protein present in nearly every cell and involved in repair and cell migration. It is one of the most-studied peptides in preclinical tissue-repair research, frequently paired with BPC-157.
In animal and in-vitro models, TB-500 is investigated for its effects on cell migration and tissue repair — muscle, tendon and ligament, and wound-healing systems — largely through its regulation of the cytoskeletal protein actin. Because it targets a fundamental repair mechanism, it draws sustained interest across connective-tissue research.
Helix North supplies TB-500 strictly as a lyophilized research material for in-vitro and laboratory use. Everything on this page is written for research handling and sourcing — it is not dosing guidance and not for human use.
A synthetic fragment of Thymosin Beta-4 — TB-500 is the actin-regulating repair peptide at the centre of connective-tissue research.
Section 02 — Research
What makes TB-500 distinct is its mechanism. Rather than acting on a cell-surface receptor, it binds the cytoskeletal protein actin and shapes how cells build, move, and repair — a process upstream of many tissue-repair models.
| Research area | Model focus |
|---|---|
| Muscle | Repair & recovery |
| Tendon & ligament | Connective-tissue repair |
| Wound healing | Cell migration |
| Vascular | Angiogenesis |
The unifying mechanism is actin regulation — TB-500 binds G-actin and influences actin polymerisation, which governs how cells migrate to and rebuild damaged tissue. This is preclinical, mechanism-level research; none of it constitutes evidence of a human therapeutic effect.
For the full picture, our what is TB-500 explainer goes deeper, and the BPC-157 + TB-500 (Wolverine stack) article covers how it is studied alongside BPC-157 for connective-tissue research.
Section 03 — Product
TB-500 is stocked as a 10 mg lyophilized vial, and as pre-blended BPC-157 + TB-500 research vials — the “Wolverine” blend — for connective-tissue work. Each vial ships freeze-dried with a Certificate of Analysis for its specific lot.
Every lot is sent to an independent third-party laboratory for HPLC purity analysis, with identity confirmed by mass spectrometry. We do not release a lot below 99 percent purity, and the CoA — lot number, chromatogram, and calculated purity — is published on the product page so you can review it before ordering. That verification is the whole point of sourcing from an accountable supplier rather than an anonymous vendor.
Choose a form below, or read how each lot is tested on our lab testing and CoA page.
Section 04 — Handling
TB-500 ships freeze-dried and is reconstituted with bacteriostatic water before use. The diluent volume is the only real decision, because it sets the concentration of the finished research stock — concentration is simply mass divided by volume.
Wipe both stoppers with an alcohol prep pad, draw the chosen volume of bacteriostatic water into an insulin syringe, and add it slowly down the inside wall of the vial. Swirl gently until clear — never shake — then refrigerate at 2 to 8°C. A 10 mg vial reconstituted with 2 mL gives a 5 mg/mL stock; the same vial with 5 mL gives 2 mg/mL.
Our step-by-step reconstitution guide works the concentration math, and the storage guide covers stability. These are reconstitution mechanics for laboratory handling only — not dosing recommendations.
Section 05 — Sourcing
Sourcing TB-500 domestically removes the two problems that come with an offshore order: the customs wait and the currency markup. A Canadian-domestic shipment never crosses a border, so there is no customs hold and no risk of a package being detained or returned mid-protocol.
Helix North makes its peptides in Canada and ships TB-500 from British Columbia by Canada Post Xpresspost — 1 to 2 business days on the West Coast, 2 to 4 for central Canada, a flat $30 to any postal code, tracked and in plain packaging. Pricing is in Canadian dollars, so the number on the product page is the number on the receipt.
TB-500 is legal to purchase and possess for research in Canada and is not a controlled substance. It is supplied strictly as a research material. New here? The Canadian research peptides overview covers testing and shipping, and our BPC-157 + TB-500 (Wolverine stack) article covers the blend most researchers pair it with.
Section 06 — Common questions
Choose a 10 mg vial or a BPC/TB “Wolverine” blend with a third-party CoA, or browse the full research line. Questions about lots or bulk quantities — get in touch.